literature
Selected publications:.
Escribá, P.V., Busquets, X., Inokuchi, J., Balogh, G., Török, Z., Horváth, I., Harwood, J.L., Vígh, L. (2015) Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Prog. Lipid. Res. 59, 38-53.
Fulop F, Vigh, L., Torok Z., Penke, B., Horvath, I., Balogh, G., Bernath, S., Hunya, Á. (2013) 1,4 dihydropyridine derivatives with HSP modulating activity. PCT. Int. Appl., WO2013076516A2013076511
Hooper PL, Balogh G, Rivas E, Kavanagh K, Vigh L.Cell Stress Chaperones. 2014 Feb 13. [Epub ahead of print] The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes.
Hooper PL, Hooper PL, Tytell M, Vígh L. Cell Stress Chaperones. 2010 Nov;15(6):761-70. Xenohormesis: health benefits from an eon of plant stress response evolution.
Hooper, P.L., Durham, H.D., Török, Z., Hooper, P.L., Crul, T., Vígh, L. (2016) The central role of heat shock factor 1 in synaptic fidelity and memory consolidation. Cell Stress Chaperones 21, 745-753
Horváth I, Glatz A, Nakamoto H, Mishkind ML, Munnik T, Saidi Y, Goloubinoff P,Harwood JL, Vigh L. (2012) Heat shock response in photosynthetic organisms: membrane and lipid connections. Prog Lipid Res. 51:208-20.
Horváth I, Vígh L. (2010) Cell biology: Stability in times of stress. Nature. 28; 463:436-8.
Kasza, Á., Hunya, Á., Frank, Z., Fülöp, F., Török, Z., Balogh, G., Sántha, M., Bálind, Á., Bernáth, S., Blundell, K.L., Prodromou, C., Horváth, I., Zeiler, H-J., Hooper, P.L., Vigh, L., Penke, B. (2016) Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimers Disease.J. Alzheimers Dis. 53, 557-571.
Nagy E, Balogi Z, Gombos I, Akerfelt M, Bjorkbom A, Balogh G, Torok Z, Maslyanko A, Fiszer-Kierzkowska A, Lisowska K, Slotte PJ, Sistonen L, Horvath I, Vigh L. (2007) Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line.Proc. Natl. Acad. Sci. USA 104, 7945-7950
Török, Z, Tsvetkova, N.M., Balogh, G., Horváth, I., Nagy, E., Pénzes, Z., Hargitai, J., Bensaude, O., Csermely, P., Crowe, J.H., Maresca, B. & Vígh, L. (2003) Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase. Proc. Natl. Acad. Sci. USA 100, 3131-3136.
Török, Z., Crul, T., Maresca, B., Schütz, G.J., Viana, F., Dindia, L., Piotto, S., Brameshuber, M., Balogh, G., Péter, M., Porta, A., Trapani, A., Gombos, I., Glatz, A., Gungor, B., Peksel, B., Vigh, L. Jr., Csoboz, B., Horváth, I., Vijayan, M.M., Hooper, P.L., Harwood, J.L., Vigh, L. (2014) Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications. BBA 1838, 1594-1618
Vígh, L. Literáti, P.N., Horváth, I.,Török, Z., Balogh, G., Glatz, A., Kovács, E., Boros, I., Ferdinándy, P., Farkas, B., Jaszlits, L., Jednákovics, A., Korányi, L. & Maresca, B. (1997) Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nature Medicine, 3, 1150-1154.
Vigh, L., Horvath, I., Maresca, B., Harwood, J.L. (2007) Can stress protein response be controlled by ‘membrane-lipid therapy’? Trends. Biochem. Sci. 32, 357-363.
Vígh, L., Maresca, B., Harwood, J.(1998) Does the membrane’s physical state control the expression of heat shock and other genes? Trends in Biochem. Sci.23, 369-374.
Vigh, L., Torok, Z., Balogh, G., Glatz, A., Piotto, S., Horvath, I. (2007) Membrane-regulated stress response: a theoretical and practical approach. Adv Exp Med Biol. 594, 114-31.